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Index > Protein center > HCRTR1(Gene name) > Human
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  • HCRTR1 (Gene name),
  • Orexin receptor type 1 (Protein name ),  OX1R_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HCRTR1;
    Protein name:
    Orexin receptor type 1(Ox-1-R;Ox1-R;Ox1R);
    Alternative:
    Hypocretin receptor type 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    425
    Sequence:
    50:
    MEPSATPGAQ | MGVPPGSREP | SPVPPDYEDE | FLRYLWRDYL | YPKQYEWVLI | 
    100:
    AAYVAVFVVA | LVGNTLVCLA | VWRNHHMRTV | TNYFIVNLSL | ADVLVTAICL | 
    150:
    PASLLVDITE | SWLFGHALCK | VIPYLQAVSV | SVAVLTLSFI | ALDRWYAICH | 
    200:
    PLLFKSTARR | ARGSILGIWA | VSLAIMVPQA | AVMECSSVLP | ELANRTRLFS | 
    250:
    VCDERWADDL | YPKIYHSCFF | IVTYLAPLGL | MAMAYFQIFR | KLWGRQIPGT | 
    300:
    TSALVRNWKR | PSDQLGDLEQ | GLSGEPQPRA | RAFLAEVKQM | RARRKTAKML | 
    350:
    MVVLLVFALC | YLPISVLNVL | KRVFGMFRQA | SDREAVYACF | TFSHWLVYAN | 
    400:
    SAANPIIYNF | LSGKFREQFK | AAFSCCLPGL | GPCGSLKAPS | PRSSASHKSL | 
    425:
    SLQSRCSISK | ISEHVVLTSV | TTVLP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ox-1-R
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    E0984h
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    ELISA Kit for Human Ox-1-R
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    ELISA Kit for Human Ox-1-R
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    E0984m
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    ELISA Kit for Human Ox-1-R
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    E0984r
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    ELISA Kit for Human Ox-1-R
    Cat.:
    E0984b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ox-1-R
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    U0984m
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    Packing:
    96T
    CLIA Kit for Human Ox-1-R
    Cat.:
    U0984r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ox-1-R
    MSDS:
    Please sign in first.
    CLIA Kit for Human Ox-1-R
    Cat.:
    U0984h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Ox-1-R
    Cat.:
    U0984b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ox-1-R
    Polyclonal Antibody for Human Ox-1-R
    Cat.:
    P0984Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ox-1-R
    Polyclonal Antibody for Human Ox-1-R
    Cat.:
    P0984Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ox-1-R
    Cat.:
    P0984Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ox-1-R
    Monoclonal Antibody for Human Ox-1-R
    Monoclonal Antibody for Human Ox-1-R
    Monoclonal Antibody for Human Ox-1-R
    Monoclonal Antibody for Human Ox-1-R
    Protein for Human Ox-1-R
    Protein for Human Ox-1-R
    Protein for Human Ox-1-R
    Protein for Human Ox-1-R
    Protein for Human Ox-1-R

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    References
    1. 1.
      "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
      Sakurai T. , Amemiya A. , Ishii M. , Matsuzaki I. , Chemelli R.M. , Tanaka H. , Williams S.C. , Richardson J.A. , Kozlowski G.P. , Wilson S. , Arch J.R.S. , Buckingham R.E. , Haynes A.C. , Carr S.A. , Annan R.S. , McNulty D.E. , Liu W.-S. , Terrett J.A. , more...
      Cell92:573-585(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains."
      Peyron C. , Faraco J. , Rogers W. , Ripley B. , Overeem S. , Charnay Y. , Nevsimalova S. , Aldrich M. , Reynolds D. , Albin R. , Li R. , Hungs M. , Pedrazzoli M. , Padigaru M. , Kucherlapati M. , Fan J. , Maki R. , Lammers G.J. , more...
      Nat. Med.6:991-997(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
      Olafsdottir B.R. , Rye D.B. , Scammell T.E. , Matheson J.K. , Stefansson K. , Gulcher J.R.
      Neurology57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-167; GLN-279; HIS-281 AND VAL-408
    4. 4.
      "Genomic sequence of the hypocretin (orexin) receptor 1 (HCRTR1)."
      Yeager M. , Welch R. , Haque K. , Bergen A.
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-408
      tissue: Brain.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M. , Mignot E.
      Bioessays23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    10. 10.
      "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T. , Chemelli R.M. , Sinton C.M. , Yanagisawa M.
      Annu. Rev. Neurosci.24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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